• AO/PI Staining Solution for Kidney Cell Assays

  2026-08-21

  AO/PI Staining Solution strengthens diabetic nephropathy workflows by separating membrane-intact cells from dead cells during fluorescence-based cell counting. Its dual-dye readout complements mechanistic studies of phillygenin, helping researchers distinguish genuine treatment effects from debris, red blood cell interference, or unstable cell preparations.

• MMP-2 Responsive Liposomes for Sequential Immunotherapy

  2026-08-21

  The reference study developed an MMP-2-responsive, dual-targeting liposome that sequentially delivers the PD-1/PD-L1 blockade peptide AUNP-12 and the IDO inhibitor NLG919. Its cascade-targeting design aims to restore T-cell activity while reducing tumor-associated immunosuppression in breast cancer, offering a mechanistic framework for combination nanomedicine.

• Toremifene vs Tamoxifen in Advanced Breast Cancer

  2026-08-20

  This Cochrane review synthesized randomized evidence comparing two endocrine therapies for advanced breast cancer and found no convincing difference in tumor response, disease control, progression, or overall survival. Its main contribution is a structured assessment showing that the available evidence supports broadly comparable efficacy while also highlighting limitations in trial reporting, safety estimates, and applicability to contemporary oncology.

• Bazedoxifene and IL-6/GP130 Signaling in Cancer

  2026-08-20

  Shi et al. review Bazedoxifene as a repurposing candidate that may inhibit IL-6/GP130 protein–protein interaction and downstream oncogenic signaling beyond its established role as a selective estrogen receptor modulator. The evidence supports further preclinical investigation of Bazedoxifene alone and in combination regimens, while emphasizing that clinical anticancer efficacy remains unproven.

• Sodium Oxamate in TNBC Metabolism Workflows

  2026-08-19

  Sodium Oxamate is a practical LDH-A perturbation tool for connecting glycolytic lactate production with apoptosis, histone lactylation, and SLFN5 regulation in triple-negative breast cancer models. This workflow-focused guide covers aqueous preparation, paired lactate experiments, assay selection, dose optimization, and troubleshooting for cancer metabolism research.

• AICAR Phosphate: AMPK Activation Workflows

  2026-08-19

  AICAR phosphate (Acadesine) combines intracellular AMPK activation with a measurable apoptotic phenotype, making it useful for B-CLL dose-response and mechanism studies. This guide connects validated cancer workflows with a carefully bounded hypothesis-testing strategy for hypoxia, macrophage polarization, and choroid plexus barrier research.

• Flubendazole Workflows for Autophagy Research

  2026-08-18

  Build more informative Flubendazole experiments by separating growth inhibition from actual cell killing and pairing viability with autophagy-specific readouts. This workflow uses DMSO handling, time-course design, and orthogonal assays to improve cancer biology research and translational model interpretation.

• SPRTN Ubiquitin Binding and DPC Proteolysis

  2026-08-18

  This bioRxiv preprint identifies a ubiquitin-binding region, the Ubiquitin interface of SprT Domain (USD), within the N-terminal catalytic region of SPRTN. The findings indicate that ubiquitin chains are not merely marks on DNA-protein crosslinks (DPCs); they directly stimulate SPRTN proteolysis, producing approximately 67-fold greater activation toward polyubiquitinated DPCs than toward unmodified lesions.

• N6-Methyl-dATP for DNA Fidelity and AML Assays

  2026-08-17

  N6-Methyl-dATP enables controlled, cell-free testing of how adenine methylation alters DNA polymerase recognition, extension, and fidelity. This workflow connects nucleotide chemistry with AML transcriptional biology while emphasizing matched controls, quantitative readouts, and practical troubleshooting.

• L-Ornithine Workflows for Urea Cycle Research

  2026-08-16

  L-Ornithine enables controlled studies of OTC activity, ammonia detoxification, and liver–brain metabolic signaling in both enzyme and cell-based systems. This practical guide connects reagent preparation with the realgar toxicity findings that implicate ornithine accumulation and astrocyte glycolysis.

• Mianserin HCl: From Receptor Biology to Translation

  2026-08-15

  Mianserin HCl offers translational researchers a useful bridge between serotonin receptor pharmacology, antidepressant research, and emerging antipathogenic assays. This article examines its mechanism, evidence base, assay strategy, formulation considerations, competitive position, and the limits that should guide responsible experimental interpretation.

• NP-40 Lysis Buffer for Neuroimmune Protein Assays

  2026-08-15

  NP-40 Lysis Buffer provides a mild, non-denaturing route to protein extracts when neuroinflammation studies depend on intact signaling complexes as well as reliable immunoblotting. This workflow translates findings on FPR2/ALX, microglia, NK cells, and SYK-AKT signaling into practical sample-preparation choices for tissue, cell, IP, Co-IP, and ELISA assays.

• Ziprasidone HCl Research Workflows

  2026-08-14

  Ziprasidone HCl supports two complementary research directions: receptor-driven neuroscience assays and GOT1-centered cancer metabolism studies. Its poor aqueous solubility also makes it a practical benchmark for solid-dispersion, permeability, and food-effect experiments.

• Artesunate: From IC50 to Cell-Killing Biology

  2026-08-14

  Artesunate is an artemisinin derivative with applications in ferroptosis, pyroptosis, and cancer-response studies. This guide explains how to distinguish growth inhibition from true cell killing and design more interpretable assays.

• Methicillin sodium salt: Reliable Assay Design

  2026-08-13

  Learn how Methicillin sodium salt (SKU C3238) can support controlled MSSA susceptibility testing and infection-associated cell viability workflows. This scenario-based guide distinguishes bacterial effects from mammalian assay artifacts, explains MIC interpretation, and provides practical preparation and vendor-selection criteria.

449 records 7/30 page Previous Next First page 上5页 678910 下5页 Last page